TSXV: NTB - NASDAQ: NEPT
Basic Shares: 48.2 million
Fully diluted: 53.9 million
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Neptune Technologies & Bioressources
Neptune Technologies & Bioressources
It should be of interest to Neptune shareholders that there’s a bit more colour to be shared around yesterday’s (November 16) announcement that it had been granted another U.S. patent; this time for the exclusive use of krill extracts in the United States as a method for reducing cholesterol, platelet adhesion and plaque formation.
The news came on the heels of last month’s announcement that, “U.S. patent No. 8,030,348 secured Neptune's intellectual property on a composition of novel omega-3 phospholipids, which are the main bioactive ingredients in all krill oils.”
This latest patent finally came to fruition from an initial application to the U.S. patent office that was made in 2001. It was supplemented in 2003 with data obtained from a 3 month clinical study of 120 people with moderate to high cholesterol.
In our discussion with management, it was clarified that the people in the study were provided a daily dosage of 1.0 to 1.5 grams/day (2 to 3 soft gel caps) of Neptune NKO™.
The study proved an average 33% decrease in LDL, which is the aspect covered by the new U.S. patent grant.
The clinical data graphical information is available by clicking on the graphic.
We are told that approximately 100 of the 120 patients were resistant to statins and failed to attain their target LDL levels after at least six months on low dosages.
This new U.S. patent deals with LDL but importantly is one “division” of Neptune’s original patent application. The company is awaiting word from the U.S. patent office on the HDL and Triglyceride components of the application.
Of note, the company expresses no opinion on the timing or the outcome of an announcement from the U.S. patent office.
However, should Neptune be granted patents based on the clinical study’s positive HDL and Triglyceride results with NKO™ versus fish oil, it would be the “perfect trifecta”, which is to simultaneously influence HDL, LDL and Triglycerides while also offering a natural alternative to people resistant to statins.
The “perfect trifecta” is a phrase coined by Dr. Tina Sampalis who is President of Acasti Pharma, 58% owned by Neptune.
Her presentation at The Howard Group’s annual Opportunity Knocks investor conference can be viewed through this link.
The granting of the two patents is also a major benefit to Acasti Pharma (APO – TSX V), which is 58% owned by Neptune. Acasti Pharma is focused on bringing to market, highly purified forms of NKO® (Krill oil) for cardiovascular/cholesterol applications. Acasti’s, CaPre™ is a pharma grade drug candidate that entered a Phase II Clinical Trial in late Q3/2011. Acasti recently commercialized two products in the over-the-counter and medical food areas.
Still on the topic of patents, today Neptune issued a direct and pointed response to the quick filing of a re-examination request of the latest patent by its main competitor, Norway headquartered Aker Biomarine.
The following sums up the position of Neptune management, “Unfortunately, Aker's press release announcing its re-examination request, as well as other related statements made by Aker to the press, appear designed to mislead the public about the validity of Neptune's patent rights and the re-examination process.
It’s clear the two tough competitors are going to remain at loggerheads for some time. Unfortunately, this causes some level of investor discomfort until there is an absolute final answer as to whether or not the U.S. Patent Office will re-examine the patent grants. The timing on that question being answered is unknown. It also wouldn’t be surprising if Aker follows this tact on patents that Neptune is granted in the future.
To read the news release click here.

Carfinco Income Fund
VentriPoint Diagnostics has reached a key milestone with today’s announcement that an initial Pulmonary Arterial Hypertension validation trial has started at The University of Chicago Medical Center.
This is significant for the company as the VMS™ PAH (Pulmonary Arterial Hypertension) Diagnostic tool is focused on a very large market. In the U.S. alone, there are about 200,000 hospitalizations annually from PAH alone.
What Is Pulmonary Hypertension?
Pulmonary hypertension, or PH, is increased pressure in the pulmonary arteries. These arteries carry blood from the heart to lungs to pick up oxygen.
PH causes symptoms such as shortness of breath during routine activity (for example, climbing two flights of stairs), tiredness, chest pain, and a racing heartbeat. As the condition worsens, its symptoms may limit all physical activity.
Overview
To understand PH, it helps to understand how your heart and lungs work. Your heart has two sides, separated by an inner wall called the septum.
Each side of your heart has an upper and lower chamber. The lower right chamber of your heart, the right ventricle, pumps blood to your pulmonary arteries. The blood then travels to your lungs, where it picks up oxygen.
The upper left chamber of your heart, the left atrium, receives the oxygen-rich blood from your lungs. The blood is then pumped into the lower left chamber of your heart, the left ventricle. From the left ventricle, the blood is pumped to the rest of your body through an artery called the aorta.
PH begins with inflammation and changes in the cells that line your pulmonary arteries. Other factors also can affect the pulmonary arteries and cause PH. For example, the condition may develop if:
These changes make it hard for your heart to push blood through your pulmonary arteries and into your lungs. As a result, the pressure in your arteries rises. Also, because your heart is working harder than normal, your right ventricle becomes strained and weak.
Your heart may become so weak that it can't pump enough blood to your lungs. This causes heart failure. Heart failure is the most common cause of death in people who have PH.
PH is divided into five groups based on its causes. In all groups, the average pressure in the pulmonary arteries is higher than 25 mmHg at rest or 30 mmHg during physical activity. The pressure in normal pulmonary arteries is 8–20 mmHg at rest. (The mmHg is millimeters of mercury—the units used to measure blood pressure.)
Other diseases or conditions, such as heart and lung diseases or blood clots, usually cause PH. Some people inherit the condition (that is, their parents pass the genes for PH on to them). In some cases, the cause isn't known.
According to the Thoracic Society of America better tests are needed to make an early diagnosis. The tests should be convenient for screening and could identify persons at risk or give a measure of how severe the disease is.
What is currently available, however, does not adequately assess either risk or severity. Until now.
What Does This Mean For VentriPoint?
Should the trial produce the desired results, the VMS™ PAH system may be the highly accurate, economic and rapid results diagnostic solution that has been sought by cardiologists.
In the news release Dr. Roberto Lang, former President of the American Society of Echocardiography and Director of the Echo Lab states:
“I expect that an assessment of RV volume and function using the VMS™ will become part of the routine clinical ultrasound evaluation for patients at risk for PAH. A simple way to detect and monitor PAH is gravely needed and this methodology will be extremely useful to quantify interventions (therapeutic and surgical) performed on the right ventricle”
Dr. Adams, VentriPoints CEO, comments about the process and what he expects to happen;
“This is a first clinical validation test which should take about 4-6 weeks. When this validation is over we will start the pivotal clinical trial just like the TOF (Tetralogy of Fallot) trial we have ongoing right now.
We estimate the PAH market to be somewhere between $1-2B annually and we are the only company with a solution.
PAH has been identified to us by most of the large ultrasound companies as an application they would love to be able to do but have been unable to figure how. We are discussing with a number of companies how we could partner to bring to market an integrated system for PAH. It is exciting times at VentriPoint.”
Indeed, this is exciting times for VentriPoint.
See the full press release here: